Selected from data included with permission and copyrighted by First Databank, Inc. Thompson LU, Rickard SE, Cheung F, et al. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Flaxseed: a potential treatment for lupus nephritis. Nordstrom DC, Honkanen VE, Nasu Y, et al. Ibrgger S, Kristensen M, Mikkelsen MS, Astrup A. Flaxseed dietary fiber supplements for suppression of appetite and food intake. Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W. Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. JAMA 2005;294:1493-1504. May cause allergic reactions. Hadi A, Askarpour M, Salamat S, Ghaedi E, Symonds ME, Miraghajani M. Effect of flaxseed supplementation on lipid profile: An updated systematic review and dose-response meta-analysis of sixty-two randomized controlled trials. Nutr Cancer 1999;33:188-95. Often youll need to take flaxseed oil a few hours before administering medications to make sure your body absorbs them properly. 2018 Feb 1;76(2):125-39. Let's Find Out Reprod Toxicol 2007;23:397-406. Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder. View abstract. Read about how you can use flaxseed oil . What should I know regarding pregnancy, nursing and administering Flaxseed to children or the elderly. We avoid using tertiary references. Lancet 1982;2:1295-9. Chen J, Power KA, Mann J, et al. 2019:1-8. It is not certain whether flax is effective in treating any medical condition. Anticancer Res 1998;18:1405-8. Mani UV, Mani I, Biswas M, Kumar SN. Wang C, Makela T, Hase T, et al. 2015;145:758. There are many studies currently under way to link the use of flaxseed oil with positive health benefits, but there is no standard use of the supplement. Cunnane SC, Hamadeh MJ, Liede AC, et al. Low adherence may be a contributing factor leading to uncontrolled blood pressure in patients. Answer: Method 1 of 2:Taking Flaxseed Oil It is important to ask your doctor about adding flaxseed oil to your diet, especially if you are taking certain medications. J Am Coll Nutr 2008;27:65-74. J Nutr 2006;136:3046-53. Dietary lignans and postmenopausal breast cancer risk by oestrogen receptor status: a prospective cohort study of Swedish women. Cancer Epidemiol Biomarkers Prev 2006;15:1132-6. Flaxseed and prostate cancer risk. Polypodium Leucotomos - Inotersen. Int J Cancer 2006;119:925-31. View abstract. Leon F, Rodriguez M, Cuevas M. Anaphylaxis to Linum. Complement Ther Med. A prospective study of dietary fat and risk of prostate cancer. Flax has been used in alternative medicine as a possibly effective aid in treating type 2 diabetes, high cholesterol, and some autoimmune diseases such as systemic lupus erythematosus (SLE). Flaxseed oil might lower blood pressure. Meta-analysis of the effects of flaxseed interventions on blood lipids. 5 Science-Based Benefits of 5-HTP (Plus Dosage and Side Effects), The 15 Best Vitamin Brands of 2023: A Dietitians Picks, Red Raspberry Leaf Tea: Pregnancy, Benefits, and Side Effects. If we combine this information with your protected If you have a condition or take a medication that lowers your blood pressure, adding this supplement to your diet could cause complications. 2019;46:36-43. Fish, walnuts, chia seeds and flaxseed oil are excellent sources of omega-3 fats. Br J Nutr. Accessed Sept. 27, 2017. These medications may cause some risk when taken together. View abstract. Possible drug interactions: Can reduce blood levels and effectiveness of many drugs, including birth control pills, cholesterol-lowering statins and some anti-HIV drugs. Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Flaxseed oil. Other drugs may interact with flax, including prescription and over-the-counter medicines, vitamins, and herbal products. Lewis JE, Nickell LA, Thompson LU, et al. View abstract. Flaxseed consumption may reduce blood pressure: A systematic review and meta-analysis of controlled trials. Is Flaxseed Good for Thyroid? Learn about the medical uses, claims, and side effects of flaxseed. Am J Epidemiol 2008;167:734-42. Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. Effect of a homemade salivary substitute prepared using chamomile (Matricaria chamomilla L.) flower and flax (Linum usitatissimum L.) seed to relieve primary burning mouth syndrome: a preliminary report. Not all possible interactions are listed in this product guide. Things to remember when you fill your prescription. When taken in recommended amounts, flaxseed and flaxseed oil are generally safe to use. Black Seed Oil and Diabetes: What's Known, What's Not, Harvard T.H. Bodybuilder Darwin Uribe Will Withdraw From 2023 Arnold Classic. While over-the-counter drugs can help relieve constipation, natural remedies like flaxseed have proven to be effective in some people. Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil) Digoxin Licorice The herb licorice may lower warfarin levels and can add to digoxin's effects. Cotterchio M, Boucher BA, Manno M, et al. Raspberries - joint pain. J Natl Cancer Inst 1993;85:1571-9. Some medications that may interact with flaxseed oil negatively include: those that alter your blood flow and bleeding, including: aspirin blood thinners, like warfarin (Coumadin) and. Obes Facts 2022. Yari Z, Cheraghpour M, Hekmatdoost A. Flaxseed and/or hesperidin supplementation in metabolic syndrome: an open-labeled randomized controlled trial. Yes, several popular herbal supplements can impact the effectiveness of apixaban (Eliquis), rivaroxaban (Xarelto), betrixaban (Bevyxxa), and other anticoagulant drugs (blood-thinners) classified as direct factor Xa inhibitors. 2016 Jun;35(3):615-25. View abstract. Though flaxseed oil benefits your blood pressure, if you take blood pressure medication and supplement your diet regularly with flaxseed oil, the combination may lower your blood pressure too much. View abstract. Yari Z, Cheraghpour M, Alavian SM, Hedayati M, Eini-Zinab H, Hekmatdoost A. Natural Medicines. You should discontinue and avoid the use of flaxseed oil if you notice itching, swelling, redness, or hives when you ingest it. Dietary fat and prostate cancer: current status. It isn't always safe to take flaxseed oil with other medicines. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Am J Clin Nutr 1999;69:549-55. J Womens Health (Larchmt) 2008;17:355-66. Moderate to vigorous physical activity, particularly aerobic exercise, has been shown to be associated with lower risk of bone fractures in women being treated with aromatase inhibitors. Taking flaxseed along with medications that lower blood pressure might cause blood pressure to go too low. Flaxseed oil does not have the nutrient lignan, which has been linked to slowing tumors for prostate cancer. Select a condition to view a list of vitamins. other information we have about you. Dietary flaxseed interaction with tamoxifen induced tumor regression in athymic mice with MCF-7 xenografts by downregulating the expression of estrogen related gene products and signal transduction pathways. Journal of Nutrition. Flaxseed consumption reduces blood pressure in patients with hypertension by altering circulating oxylipins via an a-linolenic acid-induced inhibition of soluble epoxide hydrolase. Gholami Z, Akhlaghi M. The effect of flaxseed on physical and mental fatigue in children and adolescents with overweight/obesity: a randomised controlled trial. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. View abstract. 2015 Apr;145(4):749-57. The authors of the article in the Journal of Food Science and Technology call flaxseed oil a functional food because of its potential health benefits. Effects of linseeds on the symptoms of irritable bowel syndrome: a pilot randomised controlled trial. View abstract. Consuming flaxseed oil may lower your blood pressure. Chen J, Hui E, Ip T, Thompson LU. Hashempur MH, Homayouni K, Ashraf A, Salehi A, Taghizadeh M, Heydari M. Effect of Linum usitatissimum L. (linseed) oil on mild and moderate carpal tunnel syndrome: a randomized, double-blind, placebo-controlled clinical trial. Kilkkinen A, Stumpf K, Pietinen P, et al. View abstract. Pruthi S, Qin R, Terstreip SA, et al. The use of flax seeds or flaxseed oil may result in lowered blood sugar. Chan School of Public Health, 17 Reasons Why You Probably Need More Omega-3s in Your Diet, National Center for Complementary and Integrative Health. View abstract. J Nutr 2010;140:293-7. Haggans CJ, Hutchins AM, Olson BA, et al. View abstract. Mayo Clinic does not endorse any of the third party products and services advertised. Flaxseed is often mixed with foods and used in baked goods, such as muffins, breads, and snack bars. WebMD does not provide medical advice, diagnosis or treatment. The phase IV clinical study analyzes what interactions people who take Flax seed and Aspirin have. Role of Plant-Derived Omega-3 Fatty Acids in Human Nutrition. Hemodial Int. 2021;60(1):287-298. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Lampe JW, Martini MC, Kurzer MS, et al. View abstract. Shim YY, et al. National Center for Complementary and Integrative Health. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. There are 10 disease interactions with Cymbalta (duloxetine) which include: Liver Disease Renal Disease Depression Diabetes Glaucoma Hypertension Hyponatremia Mania Seizures Urinary Tract Obstruction Is it safe to eat raw flaxseed during pregnancy? This is not a complete list of side effects and others may occur. View abstract. View abstract. View abstract. View abstract. Barre DE, et al. View abstract. WebMD does not provide medical advice, diagnosis or treatment. Adlercreutz H, Fotsis T, Bannwart C, et al. Nutritional attributes of traditional flaxseed in healthy young adults. information submitted for this request. Using different formulations together increases the risk of an overdose. View abstract. This might alter the effects of flaxseed. Written by Cerner Multum. Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. Ingredients: Stichopus Horrens Extract: Gamodulin Chlorella Vitamin E (dl-alpha-tocopherol) Flaxseed oil Direction Of Use: Adult 15ml each time, twice a day Twice a day preferably to be taken on empty stomach. Fish oil may be a better and safer choice. February 23, 2023. View abstract. J Med Food. Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer. A September 2014 article published in the Journal of Food Science and Technology says flaxseed oil is the best plant source of the essential fat. Teas have been used as a natural remedy to soothe stomach upset for thousands of years. Flax seeds are considered to help with constipation. Before using flax, talk to your healthcare provider. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. Eur J Clin Nutr 1998;52:749-53. Summary: Drug interactions are reported among people who take Flaxseed and Metformin. We'll take a look at just what makes hemp oil beneficial and which conditions may improve from. Flax seed oil is in the drug class herbal products. Javidi A, Mozaffari-Khosravi H, Nadjarzadeh A, Dehghani A, Eftekhari MH. J Nutr. Rodriguez-Leyva D, Weighell W, Edel AL, LaVallee R, Dibrov E, Pinneker R, Maddaford TG, Ramjiawan B, Aliani M, Guzman R, Pierce GN. Even though the nutritional profile of flaxseeds may be useful for improving the function of the Thyroid, it is important to consider that there is also one particular concerning the fact that need to be taken into account. (2015). View abstract. If you take insulin or other medication for diabetes, consult your physician before consuming flaxseed meal. Flaxseed - More Interactions. . 2005 - 2023 WebMD LLC. Flaxseed and flaxseed oil (Linum usitatissimum). Vomiting and nausea could also be an indicator of an allergy. Most of the health benefits associated with omega-3 fatty acids from improving heart health to reducing inflammation are due to EPA and DHA, which come from fish and fish oil. Flaxseed can be used whole or crushed, or in a powder form as meal or flour. 2017 Sepl18(9):1096-1107. Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. Pan A, Sun J, Chen Y, et al. Clin Nutr ESPEN. Yari Z, Rahimlou M, Eslamparast T, Ebrahimi-Daryani N, Poustchi H, Hekmatdoost A. Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. It is created by eHealthMe based on reports of 30 people who take . 2013;23(6):446-7. The effects of dietary flaxseed on cardiac arrhythmias and claudication in patients with peripheral arterial disease (1). Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study. Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. Int J Food Sci Nutr. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. information and will only use or disclose that information as set forth in our notice of Call your doctor for medical advice about side effects. Oncology Nutrition advises that you should discuss the use of flax seeds with your doctor and avoid the use of flaxseed oil altogether because it provides no benefit to those with prostate cancer. To help you remember, take it at the same time(s) each day. are using nonsteroidal anti-inflammatory drugs. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. However, whether flaxseed oil benefits your health is still under debate, according to the National Center for Complementary and Integrative Health (NCCIH). Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. Research investigating the health benefits of flaxseed oil, however, show some promise for the plant oil. There are three primary types of omega-3s, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Flaxseed is considered to be a goitrogen. Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. Brand names: Flax Seed Oil, Flax Oil Atherosclerosis 1997;132:69-76. View abstract. View abstract. Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Systemic lupus erythematosus (SLE) nephritis, Constipation. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. It's possible that taking flaxseed oil might increase the risk of bleeding. Click here for an email preview. Rheumatol Int 1995;14:231-4. Br J Nutr 2008;101:1145-9. Chen J, Wang L, Thompson LU. Flaxseed (Linum usitatissimum) and flaxseed oil, which comes from flaxseed, are rich sources of the essential fatty acid alpha-linolenic acid a heart-healthy omega-3 fatty acid. Diarrhea Or Constipation Advertisements One likely effect is on the digestive system. Flaxseed may interfere with the absorption of some medications. If you are a Mayo Clinic patient, this could DOI: What are omega-3 fatty acids from fish oil? View abstract. Saw palmetto Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: Aspirin Clopidogrel Warfarin St. John's wort 2014 Jul;64(1):53-9. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Advertising and sponsorship opportunities. The most common medication used in women with PCOS is the insulin-sensitizer metformin. Goyal A, et al. 2005-2023 Healthline Media a Red Ventures Company. Dietary flavonoid intake and breast cancer risk among women on Long Island. Am J Clin Nutr 1997;66:591-8. Can J Physiol Pharmacol. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. View abstract. View abstract. Flaxseed can act like a laxative. Follow all directions on the product label and package. Omega-3 fats are best known for improving heart health, but your body uses the essential fat to perform many vital functions, including the formation of cell membranes and the creation of hormones that control blood clotting, blood vessel function and inflammation. Occasionally, using flaxseed or flaxseed oil causes an allergic reaction. Examples of barbiturates and medications that have barbiturate actions include: Felbatol (felbamate) Accessed Sept. 27, 2017. Phytother Res 2021;35(7):3781-3791. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Suzuki R, Rylander-Rudqvist T, Saji S, et al. Your body is an amazing physiological machine. Flax seeds are very beneficial for health because they contain a good amount of omega-3 fatty acids that cuts down the risk of heart diseases by controlling cholesterol. Serraino M, Thompson LU. J Hum Nutr Diet 2012;25:435-43. Flax is often sold as an herbal supplement. Cabbage - Sulconazole. The Mayo Clinic warns that using flaxseed oil with this blood thinner, or any other anticoagulant, may increase your risk of bleeding. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. View abstract. Information from this source is evidence-based and objective, and without commercial influence. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Cunnane SC, Ganguli S, Menard C, et al. But before you take some, you decide to do some research on the interactions it may have with some of the medications you are currently taking. Flaxseed oil, the most commonly used high risk supplement that contains phosphorus, was taken by 16 percent of patients with normal or mildly reduced kidney function. Eur J Nutr. However, when taken in large amounts and with too little water, flaxseed can cause: Avoid use of flaxseed and flaxseed oil during pregnancy. What medications does flaxseed interfere with? J Nutr 2008;138:938-45. View abstract. February 24, 2023. Use this medication regularly to get the most benefit from it. View abstract. Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. View abstract. Allergol Immunopathol (Madr) 2003;31:47-9. . Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE. Am J Epidemiol 2007;165:514-23. Some people also take flaxseed to treat inflammatory diseases. Eur.J Clin.Nutr. Int J Cancer 2005;116:793-8. You can get the same amount of omega-3 fatty acids in your body by consuming fewer fish oil capsules. Chen J, Power KA, Mann J, et al. Generic name: flax (FLACKS) Taking flaxseed by mouth seems to help reduce, Breast pain (mastalgia). However, if you're taking prescription medication, talk to your pharmacist or primary care provider about potential flaxseed oil drug interactions first. Medicinal use of this product has not been approved by the FDA. Additionally, you may have to avoid the supplement completely. J Clin Endocrinol Metab 2002;87:1527-32.. View abstract. This content does not have an Arabic version. Sonestedt E, Borgquist S, Ericson U, et al. You need to take a tablespoon of flaxseed oil to get seven grams of ALA. You may need to take up to six flaxseed oil capsules to achieve this amount in pill form. J Am Coll Nutr 2001;20:398S-402S. Other uses not proven with research have included enlarged prostate, heart disease, constipation, high blood pressure, irritable bowel syndrome, menopausal symptoms, weight loss, diverticulitis, attention deficit-hyperactivity disorder (ADHD), cancer (prostate, breast, lung, endometrial), and others. Br J Nutr 1993;69:443-53. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Giovannucci E, Rimm EB, Colditz GA, et al. View abstract. Determinants of serum enterolactone concentration. Khalatbari Soltani S, Jamaluddin R, Tabibi H, Mohd Yusof BN, Atabak S, Loh SP, Rahmani L. Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities. J Natl Cancer Inst 2007;99:475-86. However, NCCIH says the evidence that flaxseed oil has health benefits is conflicting, and more research is needed before claims can be made. Fitzpatrick says new research also suggests significant blood pressure-lowering effects of flaxseed. Grapefruit and their products contain a natural chemical that interfere with the break down of certain medications, such as simvastatin and atorvastatin. Fink BN, Steck SE, Wolff MS, et al. All rights reserved. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. The phase IV clinical study analyzes what interactions people who take Flaxseed and Anastrozole have. View abstract. Just 500 Extra Steps a Day Can Lower Heart Disease Risk in Seniors, Study Suggests . Thompson LU, Chen JM, Li T, et al. Flaxseed might lower blood pressure. Do not give any herbal/health supplement to a child without medical advice. Nutr Cancer 1990;13:1-8.. View abstract. According to Dr. Jaiswal, some of the common prescription and over-the-counter medications that interact with levothyroxine are: Antibiotics: ciprofloxacin, rifampin Seizure medications: phenytoin, fosphenytoin, and carbamazepine Antidepressants: amitriptyline, fluoxetine View abstract. Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. Sometimes flax seed will interfere with the absorption of other medications. Edel AL, Rodriguez-Leyva D, Maddaford TG, Caligiuri SP, Austria JA, Weighell W, Guzman R, Aliani M, Pierce GN. Sung MK, Lautens M, Thompson LU. J Med Food 2012;15:840-5. Flaxseed oil also might decrease blood clotting. Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. Savas BB, Alparslan GB, Korkmaz C. Effect of flaxseed poultice compress application on pain and hand functions of patients with hand osteoarthritis. However, research has shown that flax may not be effective in treating this condition. Common interactions include back pain among females and flushing among males. 2021;75(1):99-111. View abstract. Mohammadi-Sartang M, Sohrabi Z, Barati-Bodaji R, Raeisi-Dehkordi H, Mazloom Z. Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials. Cancer Epidemiol Biomarkers Prev 2000;9:719-25. Getting omega-3 into your body requires eating it in your diet or consuming it as a supplement, as your body does not produce it on its own. View abstract. Sun J, Bai H, Ma J, et al. Flaxseed oil contains ALA, which your body primarily uses as a source of energy, according to Harvard T.H. https://naturalmedicines.therapeuticresearch.com. Available for Android and iOS devices. You may report side effects to FDA at 1-800-FDA-1088. A total of 2 drugs are known to interact with Flax Seed Oil. ", Kardiologia Polska: "Linseed Oil Increases HDL3 Cholesterol and Decreases Blood Pressure in Patients Diagnosed With Mild Hypercholesterolaemia", Phytotherapy Research: "A Comparison Between the Effects of Flaxseed Oil and Fish Oil Supplementation on Cardiovascular Health in Type 2 Diabetic Patients With Coronary Heart Disease: A Randomized, Double-Blinded, Placebo-Controlled Trial", U.S. National Library of Medicine: "Warfarin". Jesus Olivares Demolishes a 465-Kilogram (1,025.1-Pound) Raw Squat PR.

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